The difference between spermicidal and non spermicidal condoms Lube and fertility: Can lube impact your chances of conceiving? Study finds PFAS in condoms and lube, prompting concerns about sperm and overall health Condoms protect against unplanned pregnancy and most sexually transmitted infections, including HIV, gonorrhoea, chlamydia, and syphilis. Use only water or silicone based lubricant with a condom during vaginal and particularly anal sex Do spermicide condoms work? Pros and cons