Vaseline as Lube Can You Use It and Is It Safe? 2018 Can you use Vaseline as lube? Learn from my experience! Say goodbye to Vaseline and spit as lubes they can lead to infections like BV and dryness. Opt for a simple water based lubricant for a smooth and safe experience. The Best Lubricants for Vaginal Dryness Olor While Vaseline, lotions and baby oil are very common moisturizers found in most homes, they should be avoided as lubricants during sex. They contain chemicals that can irritate the genitals.